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KMID : 0387720190300010065
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Korean Journal of Blood Transfusion
2019 Volume.30 No. 1 p.65 ~ p.70
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Weak D type 33 Found in a Patient with a Weak D Phenotype: The First Case in Korea
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Yu Hong-Bi
Park Jong-Eun
Park Kun
Cho Duck
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Abstract
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RHD genotyping is a useful adjunct to serologic testing. Although the use of RHD genotyping in the detection of Asia type DEL in serological D negative Koreans is gradually increasing, it is rarely requested for patients with a known weak D phenotype. This paper reports the first Korean case of a 52-year-old female patient with serologic weak D phenotype and weak D type 33 (c.520G＞A at exon 4 of RHD) identified by RHD exon 1 to 10 sequencing. In silico analysis predicted that the RHD c.520G＞A (V174M) results in a serologic weak D phenotype.
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KEYWORD
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RhD, Weak D, Phenotype, Genotyping
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